Chromosomal instability and bladder cancer: the UroVysionTMtest in the UroScreen study
BJU International(2013)
摘要
What’s known on the subject? and What does the study add?
UroVysion™ is a multicolour fluorescence in situ hybridisation assay that detects DNA gain at chromosomes 3, 7 and 17
and loss at the 9p21 locus in exfoliated urothelial cells. This cell-based test is time-consuming and costly compared with
voided urine cytology or other molecular markers for the early detection of bladder cancer.
We determined copy number changes at chromosomes 3, 7 and 17 and at the 9p21 locus with UroVysion in a
prospective screening study among chemical workers. Strong correlations between DNA gains yield a similar
performance in detecting bladder cancer with just one of the probes for chromosomes 3, 7 or 17 instead of all,
supporting the development of a simpler and cheaper assay.
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关键词
bladder cancer,chromosomal instability,uroscreen study
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