Assessing the Impact of Prenatal Irradiation in a Mouse Model: a Focus on Eye/neural Tube Development and Postnatal Viability

Event Abstract Back to Event Assessing the impact of prenatal irradiation in a mouse model: a focus on eye/neural tube development and postnatal viability Kai Craenen1, 2*, Mieke Verslegers1*, Jasmine Buset1*, Sarah Baatout1*, Lieve Moons2* and Mohammed A. Benotmane1* 1 SCK-CEN, Radiobiology Unit, Belgium 2 KU Leuven, Research group of Neural Circuit Development and Regeneration, Belgium After the Chernobyl nuclear accident and the A-bombings in Japan, it became clear that prenatal radiation exposure induces various congenital defects which affect the nervous system both at a structural and functional level. This resulted in an increased neural tube (NT)/eye defect (ED) prevalence and reduced cognition. To better understand the mechanisms that contribute to these anomalies, pregnant mice were exposed to different doses of x-rays around the time of embryonic neural tube closure (embryonic day (E)7-E9). The exposed embryos were subjected to a global macroscopic analysis at E18. From this, a high incidence of congenital anomalies such as exencephaly and EDs was observed after exposure to radiation doses of 0.5 and 1.0 Gy at E7.5. In addition, preliminary observations suggest an anomalous NT closure even at a low dose of 0.1 Gy. In order to assess the viability of mice following E7.5 radiation exposure, new born animals subjected to in utero irradiation (0.1 Gy, 0.5 Gy, 1.0 Gy) were scored for weight, physical appearance and survival. Animals exposed in utero to 0.1 and 0.5 Gy appeared normal and survived up to 10 weeks, while only few 1.0 Gy prenatally irradiated animals did survive up to 1 month after birth, in addition these animals showed several morphological anomalies. In conclusion, our results stipulate a link between prenatal exposure to ionizing radiation, especially at early embryonic development (E7.5), and the induction of congenital anomalies such as EDs/NTDs. Nevertheless additional investigations will be needed to characterize late cognitive outcome and possible countermeasures. Keywords: Neural Tube, Eye defect, Cognition, chernobyl, mouse model, Non-cancer effects Conference: 11th National Congress of the Belgian Society for Neuroscience, Mons, Belgium, 22 May - 22 May, 2015. Presentation Type: Poster presentation Topic: Neuroscience Citation: Craenen K, Verslegers M, Buset J, Baatout S, Moons L and Benotmane MA (2015). Assessing the impact of prenatal irradiation in a mouse model: a focus on eye/neural tube development and postnatal viability. Front. Neurosci. Conference Abstract: 11th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2015.89.00066 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Apr 2015; Published Online: 05 May 2015. * Correspondence: Mr. Kai Craenen, SCK-CEN, Radiobiology Unit, Mol, 2400, Belgium, kcraenen@sckcen.be PhD. Mieke Verslegers, SCK-CEN, Radiobiology Unit, Mol, 2400, Belgium, mversleg@sckcen.be Mrs. Jasmine Buset, SCK-CEN, Radiobiology Unit, Mol, 2400, Belgium, jbuset@sckcen.be PhD. Sarah Baatout, SCK-CEN, Radiobiology Unit, Mol, 2400, Belgium, sbaatout@sckcen.be Prof. Lieve Moons, KU Leuven, Research group of Neural Circuit Development and Regeneration, Leuven, Belgium, lieve.moons@bio.kuleuven.be PhD. Mohammed A Benotmane, SCK-CEN, Radiobiology Unit, Mol, 2400, Belgium, abenotma@sckcen.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Kai Craenen Mieke Verslegers Jasmine Buset Sarah Baatout Lieve Moons Mohammed A Benotmane Google Kai Craenen Mieke Verslegers Jasmine Buset Sarah Baatout Lieve Moons Mohammed A Benotmane Google Scholar Kai Craenen Mieke Verslegers Jasmine Buset Sarah Baatout Lieve Moons Mohammed A Benotmane PubMed Kai Craenen Mieke Verslegers Jasmine Buset Sarah Baatout Lieve Moons Mohammed A Benotmane Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.