Anaphylaxis due to polyethylene glycol: A case report

Polyethylene glycol (PEG) is a major component of bowel preparation solution for colonoscopy. It has been recognized as a safe and effective osmotic laxative that is rarely immunogenic. We here report a case of anaphylaxis due to PEG. A 49-year-old female came to the outpatient clinic wanting to find the cause of skin rash, nausea and respiratory difficulty after ingesting bowel evacuant solution (Clicool). She had visited local Emergency Department at the time of event and was diagnosed with anaphylaxis. We performed skin tests with components of Clicool to identify the cause of anaphylactic reactions. The result showed a positive skin response only to PEG. In contrast, skin test done in the control showed no reactions to PEG. This is the first case that revealed PEG to be an exact cause of anaphylaxis after ingesting a bowel evacuant.