Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

Andrew S Ishizuka,Kirsten E Lyke,Adam DeZure,Andrea A Berry,Thomas L Richie,Floreliz H Mendoza,Mary E Enama,Ingelise J Gordon,Lee-Jah Chang,Uzma N Sarwar,Kathryn L Zephir,LaSonji A Holman,Eric R James,Peter F Billingsley,Anusha Gunasekera,Sumana Chakravarty,Anita Manoj,MingLin Li,Adam J Ruben,Tao Li,Abraham G Eappen,Richard E Stafford,Natasha K C,Tooba Murshedkar,Hope DeCederfelt,Sarah H Plummer,Cynthia S Hendel,Laura Novik,Pamela J M Costner,Jamie G Saunders,Matthew B Laurens,Christopher V Plowe,Barbara Flynn,William R Whalen,J P Todd,Jay Noor,Srinivas Rao, Kailan Sierra-Davidson,Geoffrey M Lynn,Judith E Epstein,Margaret A Kemp,Gary A Fahle,Sebastian A Mikolajczak,Matthew Fishbaugher,Brandon K Sack,Stefan H I Kappe,Silas A Davidson,Lindsey S Garver,Niklas K Björkström,Martha C Nason,Barney S Graham,Mario Roederer,B Kim Lee Sim,Stephen L Hoffman,Julie E Ledgerwood,Robert A Seder

Nature Medicine（2016）

引用 10|浏览6

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摘要

Fifty-five percent of individuals vaccinated with an attenuated Plasmodium falciparum sporozoite vaccine remained without parasitemia after controlled human malaria infection one year later; immune correlate analysis in humans and non-human primates suggest a role for liver-resident T cells.

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Biomedicine,general,Cancer Research,Metabolic Diseases,Infectious Diseases,Molecular Medicine,Neurosciences

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