CRISP(e)R drug discovery

NATURE CHEMICAL BIOLOGY（2022）

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摘要

Pharmacological agents exert their therapeutic effects by altering the biochemical activities of drug targets and, consequently, manipulating cell and organism physiology. A new study combines CRISPR interference with metabolomic profiling to rapidly elucidate drug mechanisms of action.

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关键词

Bacteria,Chemical genetics,Mechanism of action,Metabolomics,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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