EP725 Lymphocyte-monocyte ratio predicts uterine sarcoma aggressiveness

Introduction/BackgroundThe aim of the current study is to assess the prognostic value of the lymphocyte-monocyte ratio (LMR) in patients with uterine sarcoma.MethodologyWe examined the LMR as a prognostic variable in a cohort of 66 patients with uterine sarcoma who underwent surgical resection. Patients were categorized into two groups based on the LMR using cut-off values determined by receiver operating characteristic curve (ROC) analysis. We assessed the effect of the LMR on progression-free survival (PFS) and validated the LMR as independent predictor of survival.ResultsUsing data from the whole cohort, the optimized LMR cut-off value selected using the ROC curve was 5.86 for PFS. The LMR-low and LMR-high groups included 45 (68.2%) and 21 (31.8%) patients, respectively. The 5-year PFS rates in the LMR-low and LMR-high groups were 69.0% and 94.4%, respectively (p=0.024). Via multivariate analysis, we identified FIGO, residual tumor after surgery, and LMR as the most valuable prognostic factors affecting PFS (p=0.039, p=0.018 and p=0.043, respectively).ConclusionThe LMR is an independent prognostic factor affecting the PFS of patients with uterine sarcoma.DisclosureNothing to disclose.