Construction and Characterization of a Mirror‐Image l ‐DNA i‐Motif

The first thermally stable and pH‐responsive quadruplex intercalated motif (i‐motif) structure formed by l ‐DNA is presented. Although this l ‐type i‐motif exhibits the same physiochemical properties as its d isomer, its inverted chirality and good enzymatic resistance potentially open the way to the development of new DNA materials of pharmaceutical and biological interest.