Management of Ethmoid Biphenotypic Sarcoma—A Rare Skull Base Malignancy

Background: Biphenotypic sinonasal sarcomas (BSNS) are a recently described entity within the latest WHO edition on Head and Neck tumors. Diagnosis is challenging due to similar histologic features of other sinonasal malignancies. Recent work describes improved diagnostic utility utilizing several biomarkers for improved immunoprofiling. Given the scarcity of this pathology, management remains variable and to our knowledge no studies have reviewed treatment techniques in the current literature.