Endothelial and Cardiomyocyte Dysfunction in Heart Failure with Preserved Ejection Fraction Is Attenuated via PDE9A Inhibition

N. Hamdani,D. Kolijn,M. Lodi,M. Herwig,Á. Kovács,S. Van Linthout,Z. Bagi, A. Mügge, J. Strauch,P. Haldenwang

The Thoracic and Cardiovascular Surgeon 49th Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery（2020）

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摘要

Objectives: Left ventricular diastolic dysfunction (LVDD) with impaired relaxation is characteristic of heart failure with preserved ejection fraction (HFpEF). Evidence suggests that comorbidities common to HFpEF promote a systemic inflammatory state that contributes to endothelial dysfunction. We hypothesize that oxidative stress and inflammation affect HFpEF pathophysiology by modulation of LV stiffness at least partly by changing the myocardial cGMP-PKG pathway aiming to assess specific treatment strategies in an attempt to develop tailored HFpEF therapy.

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关键词

pde9a inhibition,cardiomyocyte dysfunction,heart failure,ejection fraction,preserved ejection fraction

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