Single Cell Transcriptome Analysis Reveals Disease-Defining T Cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma

Tomohiro Aoki,Lauren C. Chong,Katsuyoshi Takata,Katy Milne,Monirath Hav,Anthony Colombo,Elizabeth Chavez,Tomoko Miyata-Takata,Vivian Lam, Chanel Ghesquiere, Daniel Kos,Talia Goodyear,Allen W. Zhang,Xuehai Wang,Saeed Saberi,Jiarui W. Ding,Pedro Farinha,Andrew P. Weng,Kerry J Savage,David W. Scott

Blood（2019）

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摘要

INTRODUCTION: Classic Hodgkin lymphoma (cHL) is uniquely characterized by an extensively dominant microenvironment composed primarily of different types of non-cancerous immune cells with a rare population (~1%) of tumor cells. Detailed characterization of these cellular components and their spatial relationship is crucial to understand crosstalk and therapeutic targeting in the cellular ecosystem of the tumor microenvironment (TME).

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