19 Therapeutic Reference Ranges of Cariprazine and Atomoxetine

Introduction The effective concentrations of psychotropic drugs should be within the therapeutic reference range. The therapeutic reference range of atomoxetine, has so far only been defined for adult patients between 200–1000 ng/ml. Cariprazine, a second-generation antipsychotic, is indicated for the treatment of schizophrenia. The therapeutic reference range is given as 10–20 ng/ml. The aim in this study is to analyze the pharmacokinetics of atomoxetine and cariprazine more precisely and to re-evaluate recommendations for the therapeutic reference range.