Synaptic Loss Predominates Neuronal Loss in a PD Model of AAV-mediated Alpha-Synuclein Overexpression in Hippocampus and Striatum

Elif Cinar,Gul Yalcin-Cakmakli,Ayse Ulusoy,Esen Saka,Bulent Elibol,Banu Cahide Tel

Nihon Yakuri Gakkai nenkai yoshishu（2018）

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Abstract

Pathological intracellular aggregation of alpha-synuclein (a-syn) plays a key role in the neurodegenerative process of Parkinson's disease (PD). The spread of a-syn pathology from the lower brainstem to the cortex lead to variable motor and non-motor symptoms clinically. Here, we aimed to recapitulate these symptoms together in one model.

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