Harmonizing the preclinical Alzheimer cognitive composite for multicohort studies.

Olivia L Hampton,Shubhabrata Mukherjee,Michael J Properzi,Aaron P Schultz,Paul K Crane,Laura E Gibbons,Timothy J Hohman,Paul Maruff,Yen Ying Lim,Rebecca E Amariglio,Kathryn V Papp,Keith A Johnson,Dorene M Rentz,Reisa A Sperling,Rachel F Buckley

Alzheimer's & Dementia（2022）

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摘要

This study proposes procedures for harmonizing the PACC that make fewer strong assumptions than the zPACC, facilitating robust multicohort analyses. This implementation of item response theory lends itself to adapting across future cohorts with similar composites. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

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cognition,Alzheimer's disease,harmonization

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