Analysis of Molecular Characteristics and Pathogen Expression of CD74a Isolated from Red sea bream (Pagrus major)

When pathogens invade fish, MHC class II and CD74 bind to the Golgi apparatus of antigen-presenting cells and are transcribed, causing an immune response. Through NGS analysis, the molecular characteristics and tissue-specific expression of PmCD74a identified in red sea bream were confirmed. As a result, PmCD74a showed high expression in the gills and intestines, and showed downward expression after pathogen infection, and then upward expression. The results of this study suggest that CD74a will play an important role in the immune process of red sea bream.