The Impact of COVID-19 on Health Care–associated Infections in Intensive Care Units in Low- and Middle-Income Countries: International Nosocomial Infection Control Consortium (INICC) Findings

Victor D. Rosenthal,Sheila Nainan Myatra，Zhilin Jin,Ruijie Yin

PLoS Computational Biology（2022）CCF BSCI 2区

Cited 39|Views22

Abstract

Background: This study examines the impact of the COVID-19 pandemic on health care-associated infection (HAI) incidence in low- and middle-income countries (LMICs). Methods: Patients from 7 LMICs were followed up during hospital intensive care unit (ICU) stays from January 2019 to May 2020. HAI rates were calculated using the International Nosocomial Infection Control Consortium (INICC) Surveillance Online System applying the Centers for Disease Control and Prevention's National Healthcare Safety Network (CDC-NHSN) criteria. Pre-COVID-19 rates for 2019 were compared with COVID-19 era rates for 2020 for central line-associated bloodstream infections (CLABSIs), catheter-associated urinary tract infections (CAUTIs), ventilator-associated events (VAEs), mortality, and length of stay (LOS). Results: A total of 7,775 patients were followed up for 49,506 bed days. The 2019 to 2020 rate comparisons were 2.54 and 4.73 CLABSIs per 1,0 00 central line days (risk ratio [RR] = 1.85, p =.0006), 9.71 and 12.58 VAEs per 1,000 mechanical ventilator days (RR = 1.29, p =.10), and 1.64 and 1.43 CAUTIs per 1,0 00 urinary catheter days (RR = 1.14; p =.69). Mortality rates were 15.2% and 23.2% for 2019 and 2020 (RR = 1.42; p <.0 001), respectively. Mean LOS for 2019 and 2020 were 6.02 and 7.54 days (RR = 1.21, p <.0001), respectively. Discussion: This study documents an increase in HAI rates in 7 LMICs during the first 5 months of the COVID-19 pandemic and highlights the need to reprioritize and return to conventional infection prevention practices. (C) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

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Key words

Surveillance,Infection control,Infection prevention,Health care-associated infection,Nosocomial infection,Hospital infection,COVID-19,Coronavirus,INICC,International nosocomial infection control consortium,Low- and middle-income countries,Developing countries

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