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Chemoprevention of Cutaneous Squamous Cell Carcinoma and Its Precursors in Solid Organ Transplant Recipients Using Topical Sirolimus: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

Sharene Chong,Ho Yi Wong, Ahmad Althabteh,Charlotte Cox,Paul H Stevenson,Susan Brown,Anthony Griffin,Nicole Isbel,Gregory Siller,H Peter Soyer,Helmut Schaider,Edwige Roy,Scott Campbell,Adele C Green,Kiarash Khosrotehrani

Journal of the American Academy of Dermatology（2022）

Cited 1|Views21
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Abstract
To the Editor: Immunosuppression in solid organ transplant recipients (SOTR) greatly increases the risk of keratinocyte cancer (KC), indisputably a significant burden in terms of morbidity, mortality, and cost. Switching calcineurin inhibitors to sirolimus is a major strategy that has resulted in a two-fold reduction in the risk of squamous cell carcinomas (SCC) but is poorly tolerated with many serious adverse events.1,2
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Key words
Organ Transplant Recipients,Squamous-Cell Carcinoma
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