PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma

Journal of Hepatology（2022）

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摘要

•ZFP64 is frequently upregulated in anti-PD1 resistant HCC.•PKCα/ZFP64/CSF1 axis is critical for triggering immune evasion and anti-PD1 tolerance.•Gö6976 and lenvatinib overcome anti-PD1 resistance by blocking the PKCα/ZFP64/CSF1 axis.•Gö6976 combined with anti-PD1 could be an effective new strategy in HCC therapy.

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关键词

zinc finger protein 64,anti-PD1 resistance,tumor microenvironment,phosphorylation modification,combination therapy

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