High plasma C5a and C5b-9 levels during quiescent phases are associated to severe antiphospholipid syndrome subsets.

Amelia Ruffatti,Marta Tonello,Antonia Calligaro,Teresa Del Ross,Maria Favaro,Margherita Zen,Antonio Carletto,Virginia Lotti, Eugenia Bertoldo,Francesco Tedesco,Ariela Hoxha,Domenico Biasi

Clinical and experimental rheumatology（2022）

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摘要

These results suggest that the persistence of high plasma C5b-9 and C5a levels during quiescent phases identifies APS patients with more severe disease who may develop rethrombosis and benefit from complement inhibition treatment during an acute disease phase.

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antiphospholipid syndrome, complement activation, complement membrane attack complex, complement system proteins, thrombosis

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