Cisplatin overcomes radiotherapy resistance in OCT4-expressing head and neck squamous cell carcinoma

Johannes Routila,Xi Qiao,Jere Weltner,Juha K Rantala,Timo Carpén,Jaana Hagström,Antti Mäkitie,Ilmo Leivo,Miia Ruuskanen,Jenni Söderlund,Marjut Rintala,Sakari Hietanen,Heikki Irjala,Heikki Minn,Jukka Westermarck,Sami Ventelä

Oral Oncology（2022）

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摘要

•OCT4 expression identifies HNSCCs that have increased radioresistance but respond to cisplatin.•Low expression of OCT4 is linked to sensitivity to radiation therapy.•OCT4 may be a key to de-escalation of HNSCC cancer therapy.•The results were validated in four clinical datasets and ex vivo drug screening.

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关键词

OCT4,Radioresistance,Cisplatin,Head and Neck cancer,Tissue microarray,HNSCC

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