Vulnerability Biomarkers for Mental Illness and Suicide Risk: Regards for the Development of Pharmacological and Psychological Therapies

•The result of the administered Multivariate Analysis showed the relationship between the independent variables genetic polymorphism, environmental domains (DMA) and social relations domain (DRS) and the dependent variables, psychological domain, physical domain and risk of suicide.•The first data table refers to the analysis of the intersections of the independente variables (fixed factors) of the 5HTT, TNF, IL-10 polymorphisms, social relationship domain (DRS) and environmental domain (DMA). A statistically significant difference was found. The last four lines indicate intersections with a tendency towards significance, whereas in the fourth line, the results indicate that in the interaction between DRS, DMA and IL-10 the variance becomes significant, that is, with a low propensity to occur by chance.•The same progression that tends to be significant is expressed in the interaction between DRS,DMA and IL-10. The interaction of these three variables, especiallywith regard to the quality of the possible outcomes of the dependent variables, points to a statistically significant difference for the risk of suicide.•The IL - 10 gene seems to increase the risk of suicide and could be configured as a diathesis factor in screening for the detection of a risk factor for suicide.