Modern aspects of free radical pathology (literature review and own research)

Today, there have been numerous studies that show the emergence and development of various pathologies accompanied by the activation of free radical reactions. It should be noted that the current clinical experience and results of experimental studies indicate the important role of oxidative stress in the formation and progression of cardiovascular pathology, and a series of reports are devoted to the study and comparison of the distinctive features of free radical lipid oxidation and proteins in patients with endothelial dysfunction and various functional classes of angina. Despite the considerable period that has elapsed since the Chernobyl disaster, the medical and biological problems of long-term effects of ionizing radiation are remaining relevant. However, it should be noted that according to some authors, the ideas of lipid peroxidation, mainly based on in vitro studies, do not meet the requirements for recognizing the existence of a metabolic process or metabolic pathway. In recent years, the Department of Internal Medicine # 3 with Phthisiology has conducted the number of multidirectional studies focused on various aspects of free radical pathology in experimental and clinical medicine on cardiology, nephrology, immunology, haematology, pulmonology, and gastroenterology. According to the results of the literature review and comprehensive analysis of the conducted research, we can point out that the study of the role of free radical processes in experimental and clinical medicine is still remaining quite relevant. The scientific search and practical value of these studies can lead to new insight in the context of an overall deterioration of the environment and exposure to negative environmental factors.