Evaluation of the Prognostic Value of Peritoneal Cytology in Patients with Endometrial Cancer: A Protocol for a Systematic Review and Meta-Analysis

ABSTRACT Background:In 1988, a new conception for cancer staging was introduced by Federation Internationale de Gynecologie et d'Obstetrique (FIGO). In addition to pathologic development, cytology played an important role in the staging. The goal of cytology was to identify hidden and microscopic extensions outside the uterus. In 2009, the system was reviewed; one of the changes was removing the cytology. The aim of this review is to evaluate the effect of cytology on the survival of patients with cancer. Methods: This protocol is reported based on the PRISMA-P guideline. We will search endometrial peritoneal washing, and any other relevant words on PubMed, Cochran, EMBASE, and Scopus databases. The eligibility criteria are: All original studies performed on patients with cancer, evaluated survival, and performed washing cytology. Only one of the non-English studies with the same respect will be included according to the research team's opinion. Also, the most recent paper among multiple articles about a single study is chosen. It should be noted that there will not be any restrictions regarding the language and publication date. For quality assessment, we will use the quality in prognosis (QUIPS) tool.  If possible, a meta-analysis will also be performed using a rndom effects model, and overall survival rates and confidence intervals will be reported. Heterogeneity will be tested by using the I2 index and Cochrane's Q test. Subgroup analysis will be performed to handle the heterogeneity. The publication bias will be assessed in the presence of 10 or more relevant articles. If there is no chance of meta-analysis, the result will be reported qualitatively. Discussion: The resulting review will provide valuable information regarding the prognostic value of cytology in patiens with cancer.