Drug-induced liver injury in a COVID-19 patient: potential interaction of remdesivir with P-glycoprotein inhibitors.

Emiel Leegwater,Anne Strik,Erik B Wilms, Liesbeth B E Bosma, David M. Burger, Thomas H. Ottens, Cees van Nieuwkoop

Clinical Infectious Diseases（2020）

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摘要

We report a case of a male with COVID-19 who developed acute hepatotoxicity related to remdesivir with probable interaction of P-glycoprotein (P-gp) inhibitors. Until further details upon this interaction become available, we recommend physicians to be cautious with the prescription of P-gp inhibitors in patients receiving remdesivir therapy.

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