PET Imaging of GPR44 by Antagonist [11C]MK-7246 in Pigs.

Pierre Cheung,Bo Zhang,Emmi Puuvuori,Sergio Estrada,Mohammad A Amin,Sofie Ye,Olle Korsgren,Luke R Odell,Jonas Eriksson,Olof Eriksson

Biomedicines（2021）

引用 0|浏览0

暂无评分

摘要

A validated imaging marker for beta-cell mass would improve understanding of diabetes etiology and enable new strategies in therapy development. We previously identified the membrane-spanning protein GPR44 as highly expressed and specific to the beta cells of the pancreas. The selective GPR44 antagonist MK-7246 was radiolabeled with carbon-11 and the resulting positron-emission tomography (PET) tracer [ 11111111

查看译文

关键词

pancreas imaging,diabetes,biomarker,PET,PTGDR2

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要