US Trends in COVID-19-Associated Hospitalization and Mortality Rates Before and After Reopening Economies

Question Did the trends in COVID-19-related hospitalizations and deaths change after states reopened their economies? Findings In this cross-sectional study of COVID-19-related hospitalizations and deaths across 47 US states between April 16 and July 31, 2020, the daily trend of hospitalizations after state reopenings was higher by 1.607 per 100 000 population. The change in the mortality rate trend was not significant. Meaning These findings suggest that data on COVID-19-related hospitalizations and mortality trends can be used to guide health policy as states make decisions to open or close activities in response to this and future pandemics. This cross-sectional study evaluates trends in hospitalization and death rates related to COVID-19 in US states between closures and reopenings of businesses and public gatherings in 2020. Importance After abrupt closures of businesses and public gatherings in the US in late spring 2020 due to the COVID-19 pandemic, by mid-May 2020, most states reopened their economies. Owing in part to a lack of earlier data, there was little evidence on whether state reopening policies influenced important pandemic outcomes-COVID-19-related hospitalizations and mortality-to guide future decision-making in the remainder of this and future pandemics. Objective To investigate changes in COVID-19-related hospitalizations and mortality trends after reopening of US state economies. Design, Setting, and Participants Using an interrupted time series approach, this cross-sectional study examined trends in per-capita COVID-19-related hospitalizations and deaths before and after state reopenings between April 16 and July 31, 2020. Daily state-level data from the University of Minnesota COVID-19 Hospitalization Tracking Project on COVID-19-related hospitalizations and deaths across 47 states were used in the analysis. Exposures Dates that states reopened their economies. Main Outcomes and Measures State-day observations of COVID-19-related hospitalizations and COVID-19-related new deaths per 100 000 people. Results The study included 3686 state-day observations of hospitalizations and 3945 state-day observations of deaths. On the day of reopening, the mean number of hospitalizations per 100 000 people was 17.69 (95% CI, 12.54-22.84) and the mean number of daily new deaths per 100 000 people was 0.395 (95% CI, 0.255-0.536). Both outcomes displayed flat trends before reopening, but they started trending upward thereafter. Relative to the hospitalizations trend in the period before state reopenings, the postperiod trend was higher by 1.607 per 100 000 people (95% CI, 0.203-3.011; P = .03). This estimate implied that nationwide reopenings were associated with 5319 additional people hospitalized for COVID-19 each day. The trend in new deaths after reopening was also positive (0.0376 per 100 000 people; 95% CI, 0.0038-0.0715; P = .03), but the change in mortality trend was not significant (0.0443; 95% CI, -0.0048 to 0.0933; P = .08). Conclusions and Relevance In this cross-sectional study conducted over a 3.5-month period across 47 US states, data on the association of hospitalizations and mortality with state reopening policies may provide input to state projections of the pandemic as policy makers continue to balance public health protections with sustaining economic activity.