Metabolic Control of æ T Cell Function
Infectious Microbes and Diseases(2021)
摘要
Metabolic change is associated with cell activities, such as signal transduction, cell differentiation, and cell cycle. In the pathogenesis of autoimmune diseases, abnormal activation of T cells is often accompanied by changes in their metabolism. Conversely, the changes of metabolites can also regulate the proliferation, differentiation, and function of T cells. As a bridge between innate and adaptive immune responses, gamma delta T cells have unique biological characteristics and functions. However, the immunometabolic mechanism of gd T cells has been a novel field for research in recent years. In this review, we summarize the influence of metabolic pathways and nutrients on gamma delta T cell function, and metabolic features of gamma delta T cell subsets, which may provide new insights in interventions targeting gamma delta T cells in disease control.
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关键词
gamma delta T cells, immunometabolism, glucose, fatty acid, amino acid, vitamins, plant extract
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