SAT0129 Trends in the incidence of cardiovascular diseases in patients with rheumatoid arthritis in spain: an observational cohort study of hospital discharges from 1999 to 2015 (TREND-AR STUDY)

Background Several changes have appeard in the last years in the management of Rheumatoid Arhritis (RA), and also a greater awareness about cardiovascular risk has emerged. However, the trend of CVDs in RA in Spain is unknown. Objectives To analyze the incidence and trend of hospital admissions for CVDs in patients with RA in Spain during the period between 1999 and 2015. Methods We performed an observational retrospective population study analyzing the spanish administrative database that includes a Minimun Basic Data Set (MBDS) of hospital admissions of patients with RA 1999-2015. We selected the MBDSs for CVDs, myocardial infarction (MI), ischemic heart disease (IHD), congestiveheart failure (CHF), cerebrovascular disease (CeVD) and aortic aneurysm (AA). Cases were identified by the presence in primary and secondary diagnosis of ICD9 codes. The population at risk was estimated through the population censuswith an estimated prevalence of RA of 0,5% (0,8% women, 0,2% men). Crude and adjusted rates were calculated, and the trend was analyzed using the Generalized Linear Model (GLM) with the year as the analysis variable. SPSS statistical package version 20 (SPSS Inc, Chicago, IL) was used. Results 338.343 RA hospital admissions were detected in the period, being 207.597 (61,3%) due to CVDs. table1 summarizes the data of the six subgroups of CVDs. Conclusions CVDs were the first cause of hospital admissions in Spain in RA patients during the period 1999-2015. Moreover, in that period there was an increasing incidence of hospital admissions due to CVDs in all the studied subgroups, being strikingly higher inmen after age-adjusted rates. An annual rate increase is estimated in all the different studied subgroups oscilating between 5 and 9% annual increasing. Disclosure of Interest: None declared