強力でWT温存的な,T790M含有EGFR変異体の不可逆的阻害剤である1‐{(3R,4R)‐3‐[({5‐クロロ‐2‐[(1‐メチル‐1H‐ピラゾール‐4‐イル)アミノ]‐7H‐ピロロ[2,3‐d]ピリミジン‐4‐イル}オキシ)メチル]‐4‐メトキシピロリジン‐1‐イル}プロパ‐2‐エン‐1‐オン(PF‐06459988)の発見
Cheng Hengmiao, K Nair Sajiv, W Murray Brion,Almaden Chau,Bailey Simon,Baxi Sangita, Behenna Doug, Cho‐Schultz Sujin,Dalvie Deepak, M Dinh Dac, P Edwards Martin,Feng Jun Li, Ferre Rose Ann, S Gajiwala Ketan, D Hemkens Michelle,Jackson‐Fisher Amy,Jalaie Mehran, O Johnson Ted, S Kania Robert,Kephart Susan,Lafontaine Jennifer, Lunney Beth, Liu Kevin K.‐C.,Liu Zhengyu,Matthews Jean,Nagata Asako,Niessen Sherry, A Ornelas Martha, T M Orr Suvi,Pairish Mason,Planken Simon,Ren Shijian,Richter Daniel,Ryan Kevin,Sach Neal,Shen Hong,Smeal Tod, Solowiej Jim,Sutton Scott, Tran Khanh,Tseng Elaine, Vernier William,Walls Marlena,Wang Shuiwang, L Weinrich Scott, Xin Shuibo,XU Haiwei,Yin Min‐Jean,Zientek Michael,Zhou Ru, C Kath John Journal of Medicinal Chemistry（2016）
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