Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1

Susan D. Aster,Donald W. Graham,Divya Kharbanda,Gool F. Patel,Mitree M. Ponpipom,Gina M. Santorelli,Michael J. Szymonifka,Steven S. Mundt,Kashmira Shah,Marty S. Springer,Rolf Thieringer,Anne Hermanowski-Vosatka,Samuel D. Wright,Jianying Xiao,Hratch J. Zokian,James M. Balkovec

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

Abstract Adamantyl triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They are active both in in vitro and in in vivo pharmacodynamic models. The synthesis and structure–activity relationships of these inhibitors are presented.

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关键词

selective inhibitors,bis-aryl

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