Synthesis and Drug Release Property of Unsaturated Polyphosphoester

Unsaturated polyphosphoester(UPPE) containing fumarate segment in the repeat units was synthesized via condensation polymerization reaction with fumaric acid, 1,2-propylene glycol and phosphorous oxychloride as the raw materials. The structure of the polymer was characterized by FT-IR and NMR (1H,13C, 31P). In vitro drug releases of the crosslinking systems of UPPE/NVP with different contents of ciprofloxacin and different mass ratios of UPPE to NVP were studied in phosphate buffer solution(pH =7.4) at 37 ℃. The results indicate that a system with a less content of ciprofloxacin releases drug more rapidly when the mass ratio of UPPE to NVP is kept constantly, and a system with a higher mass ratio of NVP to UPPE releases drug more rapidly when the content of ciprofloxacin is kept constantly.