Functional in vivo assessment of stem cell-secreted pro-oligodendroglial factors

The role of adult neural stem cells (NSCs) in demyelinating diseases of the central nervous system (CNS): Multipotent NSCs hold great potential for cell replacement in diseases and upon injury of the CNS. Originating from radial glial cells during nervous system development, adult NSCs are localized in the subgranular zone of the hippocampus and the subventricular zone (SVZ) of the lateral brain ventricles, the main neurogenic zones of the adult brain. Hippocampal precursor cells (type 1 cells) exhibiting properties of radial glial cells give rise to granule neurons through distinct intermediate precursor cells, and integrate into the hippocampal circuitry [reviewed by Kempermann et al. (2015)].