Synthesis and Antibacterial Activity of 2‐Alkoxy Penems.

Adriano Afonso,Frank Hon,N. Fett,Jay Weinstein,Ashit K. Ganguly,L. Naples,Roberta S. Hare,George H. Miller

ChemInform（1999）

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摘要

The phosphite mediated Oxalimide cyclization reaction was extended to 4-dithiocarbonates of N-oxalyl-2-azetidinones to synthesize 2-alkoxy penems 3. In general, the in vitro antibacterial potency of compounds 3 was weak compared to the highly potent 2-alkylthiopenems 2.

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