Exploring the potential for ehr-derived real-world data to reduce uncertainty in hta decision-making: a case study of long-term survival outcomes

Clinical trials are an important source of evidence for health technology appraisals (HTA). However, a key concern is uncertainty in survival due to immature data. This study investigates whether electronic health record (EHR)-derived data from the US may have the potential to reduce uncertainty in long-term outcomes, using NICE technology appraisal (TA) 531 as a case study.