POSB378 Health State Utilities Associated with Hyperphagia

Patients with rare genetic diseases of obesity, including monogenic or syndromic, often present with early-onset severe obesity and hyperphagia, characterized by an extreme, persistent, unsatisfied drive to consume food. Persistent hyperphagia-associated behaviors can lead to marked negative impact on the lives of patients. While utility values associated with general obesity are available in published literature, no published studies have estimated utilities associated with hyperphagia and any impact on patient’s quality of life beyond obesity.