Spike ripples in striatum correlate with seizure risk in two mouse models

•We recorded electrographic seizures in the striatum in two rodent models.•We identified spike ripples in rodent striatum with similar features as observed in human hippocampus and cerebral cortex.•Spike ripple rate was increased in the post-infusion ictal and interictal periods compared to pre-infusion periods.•Spike ripples are a promising translational biomarker for seizure risk in rodent models.