Serum Proteomic Characterisation in Acute Liver Failure

Background and aims Acute liver failure (ALF) is defined as a rapid onset hepatocellular dysfunction with associated coagulopathy in patients without known liver disease. Liver transplantation represents the only effective treatment for life-threatening ALF, but the decision for/against transplantation remains challenging. The aim of our study was to identify potential serum prognostic factors using a systematic mass spectrometry-based approach from hospitalized ALF patients.