VP3: Pelvic Reconstruction after Large Sacral Chordoma Resection Using Acellular Dermal Matrix and Double Pedicled Gracilis Muscle Flap Combined with Gluteal Fasciocutaneous Rotation Flap

MATERIALS AND METHODS: The unique bilaminar skin prosthesis consists of a porous biopolymer foam enriched with stable FGF2 and a layer of polymeric nanofibers. Two different models were used to measure dermal prosthesis neovascularization. The first was the Chick Chorioallantoic Membrane (CAM) assay, the second was a pig animal model and subsequent mathematical analysis of capillary density in histological samples stained with markers of neovascularization, α-SMA (α-smooth muscle actin) and anti-FVIII. The cutometry and clinical image assessment according to Yeong were performed.