Local IL-4Ra Blockade at Sites of Allergic Skin Inflammation Dampens Inflammation and Promotes S. aureus Clearance in Mice

Juan-Manuel Leyva-Castillo,Alex McGurk,Raif Geha

Journal of Allergy and Clinical Immunology（2022）

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摘要

Atopic dermatitis (AD) is characterized by Th2-dominated skin inflammation and colonization with S. aureus. Systemic IL-4Ra blockade is beneficial in AD and results in decreased skin colonization by S. aureus via mechanisms that are not well understood.

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关键词

inflammation,skin

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