Liver Fibrosis Does Not Impair Tolerance Induction by Liver Sinusoidal Endothelial Cells in Vivo

Background Liver sinusoidal endothelial cells (LSECs) contribute to the liver’s ability to induce immune tolerance. We have previously shown that LSECs can be harnessed for therapy of autoimmune disease by targeted delivery of autoantigen-peptides with nanoparticles (NPs). Yet, in liver fibrosis, LSECs undergo capillarization and acquire enhanced immunogenicity. Here we explore whether fibrotic LSECs maintain their ability to induce tolerance to NP-delivered peptides.