Advances in Chiral Gold Nano‐Assemblies and Their Bioapplication Based on Optical Properties

Chirality plays mysterious and essential roles in maintaining key biological and physiological processes. The chirality of inorganic nanoparticles has emerged as a popular research field during the last decade. Various chiral inorganic nanoparticles have been reported, such as magnetic, semiconductor, and noble metal nanoparticles, highlighting their importance in both basic research and potential practical applications. Among them, chiral gold nanoparticles and their assemblies have been widely used in biomedical research owing to their diverse morphologies, unique optical properties, and good biocompatibility. This review is a comprehensive overview of chiral gold nano-assemblies. First, the methodology to prepare chiral gold nano-assemblies according to their different types is introduced from the perspective of assembling templates. Then, the optical properties of chiral gold nano-assemblies are reviewed in detail, and their biological applications such as biosensors, bioimaging, and biocompatible therapy reagents are presented. Finally, the challenges and prospects of chiral gold nano-assemblies are discussed. It is envisioned that chiral gold nano-assemblies will play increasingly more impactful roles in biomedicine.