Ni‐Catalyzed Regioselective Cyclotrimerization of Internal Esteryl Alkynes towards Polysubstituted Benzene Rings

Chao Hou, Yan Ma, Yongqi Zhang, Huiling Xu,Yuanqi Wu,Jinbo Zhao,Yuchao Wang,Yu Liu

Helvetica Chimica Acta（2022）

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摘要

Transition-metal-catalyzed [2+2+2] cycloaddition of alkynes is a core synthetic approach to benzene rings. Herein we describe an efficient system based on inexpensive nickel catalyst and phosphine ligand that facilitate cyclotrimerization of various internal esteryl alkynes. The regioselectivity of the protocol was precisely controlled, and a series of polysubstituted benzene rings mainly composed of 1,2,4-isomers were provided.

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关键词

C-C bond formation, cycloaddition, internal esteryl alkynes, nickel, catalysis, regional selectivity

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