HPLC-DAD-ESI/MSn and UHPLC-ESI/QTOF/MSn characterization of polyphenols in the leaves of Neocarya macrophylla (Sabine) Prance ex F. White and cytotoxicity to gastric carcinoma cells

Vera Ribeiro,Federico Ferreres,Andreia P. Oliveira,Nelson G.M. Gomes,Ángel Gil-Izquierdo,Luísa Araújo,David M. Pereira,Paula B. Andrade,Patrícia Valentão

Food Research International（2022）

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摘要

•Twenty-seven phenolics identified for the first time in the monotypic genus Neocarya.•Hydroethanol leaf extract induces intrinsic mitochondrial apoptotic signalling.•N. macrophylla leaf extract leads to increased activation of caspase-9 and -3.•Pro-apoptotic effects partially rely on specific phenolic bioactives.•N. macrophylla leaves are suggested as a nourishment R&D pipelines in food industry.

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关键词

Agricultural waste management,Apigetrin,Astragalin,Bioactive food components,Chlorogenic acid,Hyperoside,Isoquercitrin,Parinari macrophylla

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