The Classic Form of Progressive Multifocal Leukoencephalopathy in Advanced Prostate Cancer: a Case Report

Progressive multifocal leukoencephalopathy (PML) is a serious and often lethal demyelinating disease of the brain that develops almost exclusively in patients with severe immunosuppression. The disease is caused by the reactivation of latent polyoma JC virus (JCV). PML occurs rarely in non-hematologic malignancies, and in this report, the authors present an uncommon case of rapidly progressing, fatal PML in a patient with advanced prostate cancer. Although uncommon, PML should be included in the differential diagnosis of white matter lesions in the oncologic population.