Fexofenadine Induced Spontaneous Ejaculations: Rare Case with Literature Review

Second-generation antihistamines (SGAHs) are used in allergic conditions such as rhinitis, allergic asthma, hay fever, and urticaria. They are well tolerated and more efficacious than first-generation antihistamines. SGAHs include fexofenadine, belastine, cetirizine, and levocetirizine. In therapeutic doses, these drugs are safe with very few and mild side effects. Here, we report a rare side effect of fexofenadine in our patient that has not been previously reported in the literature. A 25-year-old male, known case of asthma, presented with complaints of multiple episodes of spontaneous ejaculations without any sexual stimuli. He was using fexofenadine tablets for his allergic symptoms. All physical and laboratory examinations and imaging studies were unremarkable. His complaint was attributed to fexofenadine use, as he had experienced such episodes in the past when he was using the stated drug. When the drug was stopped, within 4 days, his complaint of spontaneous ejaculation resolved, and the rechallenge test was positive. Although very safe, clinicians should be vigilant for unusual and rare side effects of commonly used medicines such as fexofenadine. Rare side effects of drugs should be reported so clinicians can recognize them and choose alternate drugs for patients.