A novel intranasal administration adenoviral vector-based platform for rapid COVID-19 vaccine development
biorxiv(2022)
摘要
The coronavirus SARS-CoV-2 has a severe impact on global public health, and the emerging variants threaten the efficacy of the circulating vaccines. Here, we report that a single vaccination with a non-replicated Chimpanzee adenovirus-based vaccine against the SARS-CoV-2 B.1.617.2 variant (JS1-delta) elicits potent humoral, cellular and mucosal immunity in mice. Additionally, a single intranasal administration of JS1-delta provides sufficient protection against B.1.617.2 challenge in mice. This study indicates that Chimpanzee adenovirus type 3 (ChAd3) derived vector represents a promising platform for antiviral vaccine development against respiratory infections, and that JS1-delta is worth further investigation in human clinical trials.
### Competing Interest Statement
The authors have declared no competing interest.
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关键词
vaccine development,novel intranasal administration,vector-based
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