CpxA Phosphatase Inhibitor Activates CpxRA and is a Potential Treatment for Uropathogenic Escherichia Coli in a Murine Model of Infection

Kate R. Fortney,Sara N. Smith,Julia J. van Rensburg,Julie A. Brothwell, Jessi J. Gardner,Barry P. Katz,Nagib Ahsan,Adam S. Duerfeldt,Harry L. T. Mobley,Stanley M. Spinola

Microbiology spectrum（2022）

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摘要

The increasing prevalence of urinary tract infections (UTIs) due to antibiotic-resistant uropathogenic Escherichia coli (UPEC) is a major public health concern. Bacteria contain proteins that sense their environment and have no human homologs and, thus, are attractive drug targets.

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关键词

Escherichia coli,UPEC,CpxRA,phosphatase inhibitor,treatment

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