5-HTT genotype and inertia of negative affect in adolescents and young adults from the general population

The study aims to replicate the previous found association of 5-HTT LPR and inertia of negative affect in daily life of adolescents and young adults. Data of 877 adolescents (aged 14–21 years) of the Behavior and Mind Health (BeMIND) study (epidemiological cohort study, Dresden, Germany) were genotyped for 5- HTT LPR/rs25531, grouped into SS/SL G /SL A /L G L A /L G L G vs. L A L A , and provided ratings on negative affect items, depression and anxiety (Patient-Reported Outcomes Measurement Information System) eight times a day over 4 days. Multilevel regression models did not reveal an association of 5- HTT LPR genotype and inertia of negative affect, nor associations with inertia of anxiety or depression. Inertia of negative affect seems not to be a psychological mechanism through which 5-HTT LPR acts on psychopathology.