Platelet concentrates in platelet additive solutions generate less complement activation products during storage than platelets stored in plasma.

Yasmin E S de Wit,Richard Vlaar,Eric Gouwerok,Hind Hamzeh-Cognasse,Gerard van Mierlo,Ingrid Bulder,Johan W M Lagerberg,Dirk de Korte,Fabrice Cognasse,Anja Ten Brinke,Sacha S Zeerleder

Blood transfusion = Trasfusione del sangue（2023）

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摘要

Nucleosomes and HMGB1 were present in PCs prepared in plasma and PAS. Complement was activated during storage of platelets in plasma and in PAS. The use of PAS is associated with a lower amount of complement activation products due to the dilution of plasma by PAS . Therefore, PC in PAS have less complement activation products than platelets stored in plasma. These proinflammatory mediators in PC might induce FNHTR.

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关键词

platelet transfusion, platelet storage, complement activation products, nucleosomes, HMGB1

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