Bone metastasis attenuates efficacy of immune checkpoint inhibitors and displays “cold” immune characteristics in Non-small cell lung cancer

Yan-Juan Zhu,Xue-Song Chang,Rui Zhou,Ya-Dong Chen,Hao-Chuan Ma,Zhen-Zhen Xiao,Xin Qu,Yi-Hong Liu,Li-Rong Liu,Yong Li,Ya-Ya Yu,Hai-Bo Zhang

Lung Cancer（2022）

引用 9|浏览11

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摘要

•Bone metastasis attenuates efficacy of immune checkpoint inhibitors in NSCLC patients.•Bone metastasis negatively affects clinical outcomes irrespective of PD-L1 expression.•Bone metastatic NSCLC patients display “cold” immune characteristics.

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关键词

Non-small cell lung cancer,Bone metastasis,Immune checkpoint inhibitor,Tumor immune micro-environment

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