The Interplay Between Brain Vascular Calcification and Microglia

FRONTIERS IN AGING NEUROSCIENCE(2022)

引用 8|浏览12
暂无评分
摘要
Vascular calcifications are characterized by the ectopic deposition of calcium and phosphate in the vascular lumen or wall. They are a common finding in computed tomography scans or during autopsy and are often directly related to a pathological condition. While the pathogenesis and functional consequences of vascular calcifications have been intensively studied in some peripheral organs, vascular calcification, and its pathogenesis in the central nervous system is poorly characterized and understood. Here, we review the occurrence of vessel calcifications in the brain in the context of aging and various brain diseases. We discuss the pathomechanism of brain vascular calcification in primary familial brain calcification as an example of brain vessel calcification. A particular focus is the response of microglia to the vessel calcification in the brain and their role in the clearance of calcifications.
更多
查看译文
关键词
astrocyte, cerebrovascular calcification, ectopic calcification, microglia, mouse model, pericyte, primary familial brain calcification, vascular aging
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要